Girls' Night In 2021 focuses on three childhood friends who gather for their monthly dinner party. The evening takes an unexpected turn when one of them makes a comment that devastates the others, leading the friends to go their separate ways. Six months later, each woman is facing significant life changes—one struggling with her identity beyond just "beauty," another embarking on a career change, and the third preparing to have a baby alone. Through their individual trials, they eventually realize the true strength and value of their enduring friendship, learning that while they can manage alone, they are stronger and happier together.