Famke Janssen was born in Amstelveen, the Netherlands, and has two other siblings. Moving to America in the 1980s, she modeled for Chanel in New York. Later, taking a break from modeling, she attended Columbia University, majoring in literature.
This model-turned-actress broke into Hollywood in the early 1990s. Her first film was Getrennte Wege (1992). Later she became James Bond's enemy in James Bond 007: GoldenEye (1995). Her career has bloomed since then with her starring in such films as Haunted Hill (1999), Hide and Seek - Du kannst dich nicht verstecken (2005), a recurring role on FX's Nip/Tuck: Schönheit hat ihren Preis (2003), and the blockbuster movies X-Men (2000), X-Men 2 (2003), and X-Men: Der letzte Widerstand (2006).