American character actress Anne Ramsey was born Anne Mobley in Omaha, Nebraska to Eleanor (Smith), a national treasurer of the Girl Scouts, and Nathan Mobley, an insurance executive. Her uncle was U.S. Ambassador David S. Smith. An ancestor was Mayflower Pilgrim William Brewster. She attended Rosemary Hall (then an elite girls' school in Greenwich, Connecticut) and Bennington College, and was active in numerous on- and off-Broadway productions. After she married actor Logan Ramsey, the couple founded Philadelphia's Theatre of the Living Arts. In the early 1970s she began her lengthy film career. In 1971 she starred opposite her husband in The Sporting Club (1971), then settled into bit parts.
Eventually, she was noticed for her trademark brusque, gruff, usually comedic roles, after which she received more film offers, notably Der Galgenstrick (1978), Mit Vollgas nach San Fernando (1980), Die Goonies (1985), and Der tödliche Freund (1986). Unfortunately, in the mid-1980s she discovered she was suffering from throat cancer and was forced to have parts of both her tongue and jawbone removed, which obviously affected how she spoke and the effects of which are evident in Schmeiß' die Mama aus dem Zug (1987). She received an Academy Award nomination in 1987 for Best Supporting Actress for her role as Danny DeVito's inimitably nightmarish mother in Schmeiß' die Mama aus dem Zug (1987) which she managed to finish by bravely soldiering on even as her cancer remorselessly worsened. She died in 1988, aged 59, just weeks after Schmeiß' die Mama aus dem Zug (1987) was released.